저산소증이 구강편평세포암종의 상피-간엽 전환에 미치는 영향
Effects of Hypoxia on Epithelial-to-Mesenchymal Transition in Oral Squamous Cell Carcinoma
김경아, 김지영, 유미현, 박봉수, 정진, 박혜련,
소속 상세정보
김경아 ( Kim Kyung-Ah ) - 부산대학교 치의학전문대학원 구강병리학교실
김지영 ( Kim Ji-Young ) - 부산대학교 치의학전문대학원 구강병리학교실
유미현 ( Ryu Mi-Heon ) - 부산대학교 치의학전문대학원 구강병리학교실
박봉수 ( Park Bong-Soo ) - 부산대학교 치의학전문대학원 구강해부학교실
정진 ( Chung Jin ) - 부산대학교 치의학전문대학원 구강미생물학교실
박혜련 ( Park Hae-Ryoun ) - 부산대학교 치의학전문대학원 구강병리학교실
KMID : 0829220110350010007
Abstract
Malignant tumor cells outgrow new blood vessel formation and tend to be in hypoxic state. Hypoxic cancer cells adapt to hypoxic conditions by transforming its characteristics. On the other hand, one of the most important features of cancer cells is that carcinoma cells loses its inherent epithelial phenotype and acquires mesenchymal characteristics, called as epithelial-mesenchymal transition(EMT). It has been already well known that EMT contributes to tumor invasion and metastasis.
The present study investigated whether hypoxia play a major role in induction of phenotypic changes of oral squamous cell carcinoma(OSCC). Furthermore, the mechanism of EMT in oral squamous cell carcinoma cells by hypoxia has been clarified.
To mimic hypoxic condition, cobalt chloride and desferoxamine, well-known hypoxic mimetic agents, were used. This study shows that hypoxia suppresses the expression of E-cadherin(epithelial marker) and increases vimentin and N-cadherin(mesenchymal markers) in OSCC. In addition, α5 integrin protein, which is a receptor for fibronectin and an important molecule for tumor invasion, is prominently induced by hypoxia.
키워드
Hypoxia; Cobalt chloride; Epithelial mesenchymal transition; Oral squamous cell carcinoma
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